2024
Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ (2024)
Sato, M.P., Benkafadar, N., Heller, S. Cell Reports; 43 (2): 113822 PUBMED
An essential signaling cascade for avian auditory hair cell regeneration (2024)
Benkafadar, N., Sato, M.P., Ling, A.H., Janesick, A., Scheibinger, M., Jan, T.A., Heller, S. Developmental Cell; 59 (2): 280-291 PUBMED
2023
Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle (2023)
Matern, M.S., Durruthy-Durruthy, R., Birol, O., Darmanis, S., Scheibinger, M., Groves, A.K., Heller, S. Cell Reports; 42 (6): 11245 PUBMED
Inner ear cells from stem cells: a path towards inner ear cell regeneration (2023)
Janesick, A., Hashino, E., Heller, S.
Hair Cell Regeneration - Springer Handbook of Auditory Research (SHAR, volume 75); 135-162 Springer
Fbxo2 CreERT2: A new model for targeting cells in the neonatal and mature inner ear (2023)
McGovern, M.M., Hartman, B., Thawani, A., Maunsell, H., Zhang, H., Yousaf, R., Heller, S., Stone, J., Groves, A.K.
Hearing Research; 428:108686 PUBMED
2022
Cell-type identity of the avian utricle (2022)
Scheibinger, M., Janesick, A., Benkafadar, N., Ellwanger, D.C., Jan, T.J, Heller, S.
Cell Reports; 40 (13): 111432 PUBMED
Avian auditory hair cell regeneration is accompanied by JAK/STAT-dependent expression of immune-related genes in supporting cells (2022)
Janesick, A., Scheibinger, M., Benkafadar, N., Kirti, S., Heller, S.
Development; 149 (8): dev200113 PUBMED
Molecular tools to study regeneration of the avian cochlea and utricle (2022)
Janesick, A., Scheibinger, M., Heller, S.
Neuromethods: Developmental, Physiological, and Functional Neurobiology of the Inner; 176: 77-97 DOI
Immunohistochemistry and in situ mRNA detection using inner ear vibratome sections (2022)
Scheibinger, M., Janesick, A., Diaz, G. H., Heller, S.
Neuromethods: Developmental, Physiological, and Functional Neurobiology of the Inner; 176: 41-58 DOI
Editorial: Inner ear biology: Development, physiopathology, repair and recovery (2022)
Alsina, B., Heller, S., Varela-Nieto, I.
Frontiers in cell and developmental biology; 10: 1049463 PUBMED
Surgical approach for rapid and minimally traumatic recovery of human inner ear tissues from deceased organ donors (2022)
Vaisbuch, Y., Hosseini, D. K., Wagner, A., Hirt, B., Mueller, M., Ponnusamy, R., Heller, S., Cheng, A. G., Löwenheim, H., Aaron, K.A.
Otology & Neurotology : Official Publication of the American Otological Society; 43 (4): e519-e525 PUBMED
Selection criteria optimal for recovery of inner ear tissues from deceased organ donors (2022)
Aaron, K. A., Hosseini, D. K., Vaisbuch, Y., Scheibinger, M., Grillet, N., Heller, S., Wang, T., Cheng, A. G.
Otology & Neurotology : Official Publication of the American Otological Society; 43 (4): e507-e514 PUBMED
2021
Cell-type identity of the avian cochlea (2021)
Janesick, A., Scheibinger, M., Benkafadar, N., Kirti, S., Ellwanger, D. C., Heller, S.
Cell Reports; 34 (12): 108900 PUBMED
Transcriptomic characterization of dying hair cells in the avian cochlea (2021)
Benkafadar, N., Janesick, A., Scheibinger, M., Ling, A. H., Jan, T. A., Heller, S.
Cell Reports; 34 (12): 108902 PUBMED
Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea (2021)
Kubota, M., Scheibinger, M., Jan, T. A., Heller, S.
Cell Reports; 34 (3): 108646 PUBMED
Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics (2021)
Jan, T. A., Eltawil, Y., Ling, A. H., Chen, L., Ellwanger, D. C., Heller, S., Cheng, A. G.
Cell Reports; 36 (2): 109358 PUBMED
Fluorescent in situ mRNA detection in the adult mouse cochlea (2021)
Diaz, G. H., Heller, S.
STAR Protocols; 2 (3): 100711 PUBMED
Murine cochlear cell sorting and cell-type-specific organoid culture (2021)
Kubota, M., Heller, S.
STAR Protocols; 2 (3): 100645 PUBMED
2020
Hair-bearing human skin generated entirely from pluripotent stem cells (2020)
Lee, J., Rabbani, C. C., Gao, H., Steinhart, M. R., Woodruff, B. M., Pflum, Z. E., Kim, A., Heller, S., Liu, Y., Shipchandler, T. Z., Koehler, K. R.
Nature; 582 (7812): 399-404 PUBMED
Stem cell approaches and small molecules (2020)
Romano, D. R., Heller, S., Hashino , E.
The Senses: A Comprehensive Reference; 2: 945–962 DOI
2019
Single-cell proteomics reveals changes in expression during hair-cell development (2019)
Zhu, Y. n., Scheibinger, M. n., Ellwanger, D. C., Krey, J. F., Choi, D. n., Kelly, R. T., Heller, S. n., Barr-Gillespie, P. G.
eLife; 8:e50777 PUBMED
Stem cells and the bird cochlea - where Is everybody? (2019)
Janesick, A. S., Heller, S.
Cold Spring Harbor Perspectives in Medicine; 9 (4) DOI
Progenitor cells from the adult human inner ear (2019)
Senn, P., Mina, A., Volkenstein, S., Kranebitter, V., Oshima, K., Heller, S.
Anatomical Record; 303 (3): 461-470 PUBMED
Novel insights into inner ear development and regeneration for targeted hearing loss therapies (2019)
Roccio, M., Senn, P., Heller, S.
Hearing Research; 397:107859 PUBMED
2018
Transcriptional dynamics of hair-bundle morphogenesis revealed with CellTrails (2018)
Ellwanger, D. C., Scheibinger, M., Dumont, R. A., Barr-Gillespie, P. G., Heller, S.
Cell Reports; 23 (10): 2901–14.e14 PUBMED
Fbxo2(VHC) mouse and embryonic stem cell reporter lines delineate in vitro-generated inner ear sensory epithelia cells and enable otic lineage selection and Cre-recombination (2018)
Hartman, B. H., Boescke, R., Ellwanger, D. C., Keymeulen, S., Scheibinger, M., Heller, S.
Developmental Biology; 443 (1): 64–77 DOI
Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors (2018)
Roccio, M., Perny, M., Ealy, M., Widmer, H., Heller, S., Senn, P.
Nature Communications; 9: 4027 PUBMED
Aminoglycoside damage and hair cell regeneration in the chicken utricle (2018)
Scheibinger, M., Ellwanger, D. C., Corrales, C., Stone, J. S., Heller, S.
JARO - Journal of the Association for Research in Otolaryngology; 19 (1): 31 PUBMED
Hair follicle development in mouse pluripotent stem cell-derived skin organoids (2018)
Lee, J., Bӧscke, R., Tang, P. C., Hartman, B. H., Heller, S., Koehler, K. R.
Cell Reports; 22 (1): 242–254 PUBMED
Single-cell transcriptomics reveals abnormalities in neurosensory patterning of the Chd7 mutant mouse ear (2018)
Durruthy-Durruthy, R., Sperry, E. D., Bowen, M. E., Attardi, L. D., Heller, S., Martin, D. M.
Frontiers in Genetics; 9: 473 PUBMED
2017
Activity-dependent phosphorylation by CaMKIIδ alters the Ca2+ affinity of the multi-C2-domain protein otoferlin(2017)
Meese, S., Cepeda, A. P., Gahlen, F., Adams, C. M., Ficner, R., Ricci, A. J., Heller, S., Reisinger, E., Herget, M.
Frontiers in Synaptic Neuroscience; 9: 13 PUBMED
Small molecules for early endosome-specific patch clamping (2017)
Chen, C. C., Butz, E. S., Chao, Y. K., Grishchuk, Y., Becker, L., Heller, S., Slaugenhaupt, S. A., Biel, M., Wahl-Schott, C., Grimm, C.
Cell Chemical Biology; 24 (7): 907–16.e4 PUBMED
2016
Single-cell analysis delineates a trajectory toward the human early otic lineage (2016)
Ealy, M., Ellwanger, D. C., Kosaric, N., Stapper, A. P., Heller, S.
PNAS - Proceedings of the National Academy of Sciences of the United States of America; 113 (30): 8508-8513 PUBMED
Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture (2016)
Dejonge, R. E., Liu, X., Deig, C. R., Heller, S., Koehler, K. R., Hashino, E.
PloS One; 11 (9) PUBMED
Identification of novel MYO18A interaction partners required for myoblast adhesion and muscle integrity (2016)
Cao, J., Cheng, X., Li, S., Heller, S., Xu, Z., Shi, D.
Scientific Reports; 6: 36768 PUBMED
2015
Quantitative High-Resolution Cellular Map of the Organ of Corti (2015)
Waldhaus, J., Durruthy-Durruthy, R., Heller, S.
Cell Reports; 11 (9): 1385-1399 PUBMED
3D computational reconstruction of tissues with hollow spherical morphologies using single-cell gene expression data (2015)
Durruthy-Durruthy, R., Gottlieb, A., Heller, S.
Nature Protocols; 10 (3): 459-474 PUBMED
Applications for single-cell trajectory analysis in inner ear development and regeneration (2015)
Durruthy-Durruthy, R., Heller, S.
Cell and Tissue Research; 361 (1): 49-57 PUBMED
Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea (2015)
Maass, J. C., Gu, R., Basch, M. L., Waldhaus, J., Lopez, E. M., Xia, A., Oghalai, J. S., Heller, S., Groves, A. K.
Frontiers in Cellular Neuroscience; 9: 110 PUBMED
Identification and characterization of mouse otic sensory lineage genes (2015)
Hartman, B. H., Durruthy-Durruthy, R., Laske, R. D., Losorelli, S., Heller, S.
Frontiers in Cellular Neuroscience; 9: 79 PUBMED
2014
Reconstruction of the Mouse Otocyst and Early Neuroblast Lineage at Single-Cell Resolution (2014)
Durruthy-Durruthy, R., Gottlieb, A., Hartman, B. H., Waldhaus, J., Laske, R. D., Altman, R., Heller, S.
Cell; 157 (4): 964-978 PUBMED
Inner ear hair cell-like cells from human embryonic stem cells (2014)
Ronaghi, M., Nasr, M., Ealy, M., Durruthy-Durruthy, R., Waldhaus, J., Diaz, G. H., Joubert, L., Oshima, K., Heller, S.
Stem Cells and Development; 23 (11): 1275-1284 PUBMED
a-Tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion (2014)
Aguilar, A., Becker, L., Tedeschi, T., Heller, S., Iomini, C., Nachury, M. V.
Molecular Biology of the Cell; 25 (12): 1854-1866 PUBMED
Cisplatin Exposure Damages Resident Stem Cells of the Mammalian Inner Ear (2014)
Slattery, E. L., Oshima, K., Heller, S., Warchol, M. E.
Developmental Dynamics; 243 (10): 1328-1337 PUBMED
2013
Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus (2013)
Volkenstein, S., Oshima, K., Sinkkonen, S. T., Corrales, C. E., Most, S. P., Chai, R., Jan, T. A., van Amerongen, R., Cheng, A. G., Heller, S.
PNAS - Proceedings of the National Academy of Sciences of the United States of America; 110 (35): 14456-14461 PUBMED
Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells (2013)
Jan, T. A., Chai, R., Sayyid, Z. N., van Amerongen, R., Xia, A., Wang, T., Sinkkonen, S. T., Zeng, Y. A., Levin, J. R., Heller, S., Nusse, R., Cheng, A. G.
Development; 140 (6): 1196-1206 PUBMED
Special issue on inner ear development and regeneration (2013)
Heller, S.
Hearing Research; 297: 1-2 PUBMED
A novel ion channel formed by interaction of TRPML3 with TRPV5 (2013)
Guo, Z., Grimm, C., Becker, L., Ricci, A. J., Heller, S.
PLoS One; 8 (2): e58174 PUBMED
FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro (2013)
Cao, H., Yin, X., Cao, Y., Jin, Y., Wang, S., Kong, Y., Chen, Y., Gao, J., Heller, S., Xu, Z.
PLoS One; 8 (2): e56516 PUBMED
A simple method for purification of vestibular hair cells and non-sensory cells, and application for proteomic analysis (2013)
Herget, M., Scheibinger, M., Guo, Z., Jan, T. A., Adams, C. M., Cheng, A. G., Heller, S.
PLoS One; 8 (6): e66026 PUBMED
2012
Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules (2012)
Grimm, C., Joers, S., Guo, Z., Obukhov, A. G., Heller, S.
Journal of Biological Chemistry; 287 (27): 22701-22708 PUBMED
Oriented collagen as a potential cochlear implant electrode surface coating to achieve directed neurite outgrowth(2012)
Volkenstein, S., Kirkwood, J. E., Lai, E., Dazert, S., Fuller, G. G., Heller, S.
European Archives of Oto-Rhino-Laryngology; 269 (4): 1111-1116 PUBMED
Concise review: inner ear stem cells - an oxymoron, but why? (2012)
Ronaghi, M., Nasr, M., Heller, S.
Stem Cells; 30 (1): 69-74 PUBMED
Regenerative medicine for the special senses: restoring the inputs (2012)
Bermingham-McDonogh, O., Corwin, J. T., Hauswirth, W. W., Heller, S., Reed, R., Reh, T. A.
The Journal of Neuroscience; 32 (41): 14053-14057 PUBMED
2011
Serial analysis of gene expression in the chicken otocyst (2011)
Sinkkonen, S. T., Starlinger, V., Galaiya, D. J., Laske, R. D., Myllykangas, S., Oshima, K., Heller, S.
JARO - Journal of the Association for Research in Otolaryngology; 12 (6): 697-710 PUBMED
Gpr126 is essential for peripheral nerve development and myelination in mammals (2011)
Monk, K. R., Oshima, K., Joers, S., Heller, S., Talbot, W. S.
Development; 138 (13): 2673-2680 PUBMED
Intrinsic regenerative potential of murine cochlear supporting cells (2011)
Sinkkonen, S. T., Chai, R., Jan, T. A., Hartman, B. H., Laske, R. D., Gahlen, F., Sinkkonen, W., Cheng, A. G., Oshima, K., Heller, S.
Scientific Reports; 1: 26 PUBMED
2010
Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells (2010)
Oshima, K., Shin, K., Diensthuber, M., Peng, A. W., Ricci, A. J., Heller, S.
Cell; 141 (4): 704-716 PUBMED
Small molecule activators of TRPML3 (2010)
Grimm, C., Joers, S., Saldanha, S. A., Obukhov, A. G., Pan, B., Oshima, K., Cuajungco, M. P., Chase, P., Hodder, P., Heller, S.
Chemistry & Biology; 17 (2): 135-148 PUBMED
Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice (2010)
Joers, S., Grimm, C., Becker, L., Heller, S.
PLoS One; 5 (12): e14317 PUBMED
A helix-breaking mutation in the epithelial Ca2+ channel TRPV5 leads to reduced Ca2+-dependent inactivation(2010)
Lee, K. P., Nair, A. V., Grimm, C., van Zeeland, F., Heller, S., Bindels, R. J., Hoenderop, J. G.
Cell Calcium; 48 (5): 275-287 PUBMED
Characterization of stem cells derived from the neonatal auditory sensory epithelium (2010)
Diensthuber, M., Heller, S.
HNO; 58 (11): 1056, 1058, 1060 PUBMED
PIST regulates the intracellular trafficking and plasma membrane expression of Cadherin 23 (2010)
Xu, Z., Oshima, K., Heller, S.
BMC Cell Biology; 11: 80 PUBMED
Curing hearing loss: patient expectations, health care practitioners, and basic science (2010)
Oshima, K., Suchert, S., Blevins, N. H., Heller, S.
Journal of Communication Disorders: 43 (4): 311–318 PUBMED
2009
Twinfilin 2 regulates actin filament lengths in cochlear stereocilia (2009)
Peng, A. W., Belyantseva, I. A., Hsu, P. D., Friedman, T. B., Heller, S.
Journal of Neuroscience; 29 (48): 15083-15088 PUBMED
The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1 (2009)
Samie, M. A., Grimm, C., Evans, J. A., Curcio-Morelli, C., Heller, S., Slaugenhaupt, S. A., Cuajungco, M. P.
Pflugers Archiv - European Journal of Physiology; 459 (1): 79-91 PUBMED
Campaign to identify agonists of transient receptor potential channels 3 and 2 (TRPML3 & TRPML2) (2009)
Saldanha, S. A., Grimm, C., Mercer, B. A., Choi, J. Y., Allais, C. Roush, W. R., Heller, S., Hodder, P.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); PUBMED
Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells (2009)
Li, H., Liu, H., Corrales, C. E., Risner, J. R., Forrester, J., Holt, J. R., Heller, S., Edge, A. S.
BMC Neuroscience; 10: 122 PUBMED
Quo vadis, hair cell regeneration? (2009)
Brigande, J. V., Heller, S.
Nature Neuroscience; 12 (6): 679-685 PUBMED
Stem/progenitor cells derived from the cochlear sensory epithelium give rise to spheres with distinct morphologies and features (2009)
Diensthuber, M., Oshima, K., Heller, S.
JARO - Journal of the Association for Research in Otolaryngology; 10 (2): 173-190 PUBMED
Isolation of sphere-forming stem cells from the mouse inner ear (2009)
Oshima, K., Senn, P., Heller, S.
Methods in Molecular Biology; 493: 141-162 PUBMED
Life and death of sensory hair cells expressing constitutively active TRPML3 (2009)
Grimm, C., Joers, S., Heller, S.
Journal of Biological Chemistry; 284 (20): 13823-13831 PUBMED
Rethinking how hearing happens (2009)
Xu, Z., Ricci, A. J., Heller, S.
Neuron; 62 (3): 305-307 PUBMED
2008
MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23 (2008)
Xu, Z., Peng, A. W., Oshima, K., Heller, S.
Journal of Neuroscience; 28 (44): 11269-11276 PUBMED
Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development (2008)
Huang, M., Sage, C., Li, H., Xiang, M., Heller, S., Chen, Z.
Developmental Dynamics; 237 (11): 3305-3312 PUBMED
Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss (2008)
Mizoguchi, F., Mizuno, A., Hayata, T., Nakashima, K., Heller, S., Ushida, T., Sokabe, M., Miyasaka, N., Suzuki, M., Ezurai, Y., Noda, M.
Journal of Cellular Physiology; 216 (1): 47-53 PUBMED
Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3 (2008)
D'hoedt, D., Owsianik, G., Prenen, J., Cuajungco, M. P., Grimm, C., Heller, S., Voets, T., Nilius, B.
Journal of Biological Chemistry; 283 (10): 6272-6280 PUBMED
Stem-cell-based approaches for treating inner ear diseases (2008)
Senn, P., Heller, S.
HNO; 56 (1): 21-26 PUBMED
Emerging strategies for restoring the cochlea (2008)
Heller, S., Raphael, Y.
Auditory Trauma, Protection, and Repair: Springer Handbook of Auditory Research; 31: 321–338 DOI
2007
A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse (2007)
Grimm, C., Cuajungco, M. P., van Aken, A. F., Schnee, M., Jors, S., Kros, C. J., Ricci, A. J., Heller, S.
PNAS - Proceedings of the National Academy of Sciences of the United States of America; 104 (49): 19583-19588 PUBMED
Differential distribution of stem cells in the auditory and vestibular organs of the inner ear (2007)
Oshima, K., Grimm, C. M., Corrales, C. E., Senn, P., Moneder, R. M., Geleoc, G. S., Edge, A., Holt, J. R., Heller, S.
JARO - Journal of the Association for Research in Otolaryngology; 8 (1): 18-31 PUBMED
Robust postmortem survival of murine vestibular and cochlear stem cells (2007)
Senn, P., Oshima, K., Teo, D., Grimm, C., Heller, S.
JARO - Journal of the Association for Research in Otolaryngology; 8 (2): 194-204 PUBMED
LIF promotes neurogenesis and maintains neural precursors in cell populations derived from spiral ganglion stem cells (2007)
Oshima, K., Teo, D. T., Senn, P., Starlinger, V., Heller, S.
BMC Developmental Biology; 7: 112 PUBMED
Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells (2007)
Wu, L., Gao, X., Brown, R. C., Heller, S., O'Neil, R. G.
American Journal of Physiology - Renal Physiology; 293 (5): F1699-F1713 PUBMED
Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells (2007)
Jeon, S., Oshima, K., Heller, S., Edge, A. S.
Molecular and Cellular Neuroscience; 34 (1): 59-68 PUBMED
TRP channels as candidates for hearing and balance abnormalities in vertebrates (2007)
Cuajungco, M. P., Grimm, C., Heller, S.
Biochimica et Biophysica Acta - Molecular Basis of Disease; 1772 (8): 1022-1027 PUBMED
The potential role of endogenous stem cells in regeneration of the inner ear (2007)
Martinez-Monedero, R., Oshima, K., Heller, S., Edge, A. S.
Hearing Research; 227 (1-2): 48–52 PUBMED
2006
PACSINs bind to the TRPV4 cation channel - PACSIN 3 modulates the subcellular localization of TRPV4 (2006)
Cuajungco, M. P., Grimm, C., Oshima, K., D'hoedt, D., Nilius, B., Mensenkamp, A. R., Bindels, R. J., Plomann, M., Heller, S.
Journal of Biological Chemistry; 281 (27): 18753-18762 PUBMED
Reinnervation of hair cells by auditory neurons after selective removal of spiral ganglion neurons (2006)
Martinez-Monedero, R., Corrales, C. E., Cuajungco, M. P., Heller, S., Edge, A. S.
Journal of Neurobiology; 66 (4): 319-331 PUBMED
Sonic hedgehog promotes mouse inner ear progenitor cell proliferation and hair cell generation in vitro (2006)
Zhao, Y. L., Wang, Y. C., Wang, Z. M., Liu, H., SHEN, Y. Z., Li, W., Heller, S., Li, H. W.
Neuroreport; 17 (2): 121-124 PUBMED
Generation of inner ear cell types from embryonic stem cells (2006)
Rivolta, M. N., Li, H., Heller, S.
Methods in Molecular Biology; 330: 71-92 PUBMED
2005
The mechanosensitive nature of TRPV channels (2005)
O'Neil, R. G., Heller, S.
Pflügers Archiv - European Journal of Physiology; 451 (1): 193-203 PUBMED
BMP4 signaling is involved in the generation of inner ear sensory epithelia (2005)
Li, H. W., Corrales, C. E., Wang, Z. M., Zhao, Y. L., Wang, Y. C., Liu, H., Heller, S.
BMC Developmental Biology; 5: 16 PUBMED
Identification of chicken transmembrane channel-like (TMC) genes: Expression analysis in the cochlea (2005)
Mutai, H., Mann, S., Heller, S.
Neuroscience; 132 (4): 1115-1122 PUBMED
Sound from silence (2005)
Oshima, K., Heller, S.
Nature Medicine; 11 (3): 249-250 PUBMED
2004
Islet-1 expression in the developing chicken inner ear (2004)
Li, H. W., Liu, H., Sage, C., Huang, M. Q., Chen, Z. Y., Heller, S.
Journal of Comparative Neurology; 477 (1): 1-10 PUBMED
Stem cells as therapy for hearing loss (2004)
Li, H. W., Corrales, C. E., Edge, A., Heller, S.
Trends in Molecular Medicine; 10 (7): 309-315 PUBMED
Correlation of Pax-2 expression with cell proliferation in the developing chicken inner ear (2004)
Li, H. W., Liu, H., Corrales, C. E., Mutai, H., Heller, S.
Journal of Neurobiology; 60 (1): 61-70 PUBMED
Absence of the RGS9•Gß5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse (2004)
Keresztes, G., Martemyanov, K. A., Krispel, C. M., Mutai, H., Yoo, P. J., Maison, S. F., Burns, M. E., Arshavsky, V. Y., Heller, S.
Journal of Biological Chemistry; 279 (3): 1581-1584 PUBMED
Correlation of expression of the actin filament-bundling protein espin with stereociliary bundle formation in the developing inner ear (2004)
Li, H. W., Liu, H., Balt, S., Mann, S., Corrales, C. E., Heller, S.
Journal of Comparative Neurology; 468 (1): 125-134 PUBMED
2003
Generation of hair cells by stepwise differentiation of embryonic stem cells (2003)
Li, H. W., Roblin, G., Liu, H., Heller, S.
PNAS - Proceedings of the National Academy of Sciences of the United States of America; 100 (23): 13495-13500 PUBMED
Pluripotent stem cells from the adult mouse inner ear (2003)
Li, H. W., Liu, H., Heller, S.
Nature Medicine; 9 (10): 1293-1299 PUBMED
Expression patterns of the RGS9-1 anchoring protein R9AP in the chicken and mouse suggest multiple roles in the nervous system (2003)
Keresztes, G., Mutai, H., Hibino, H., Hudspeth, A. J., Heller, S.
Molecular and Cellular Neuroscience; 24 (3): 687-695 PUBMED
The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo (2003)
Martemyanov, K. A., Lishko, P. V., Calero, N., Keresztes, G., Sokolov, M., Strissel, K. J., Leskov, I. B., Hopp, J. A., Kolesnikov, A. V., Chen, C. K., Lem, J., Heller, S., Burns, M. E., Arshavsky, V. Y.
Journal of Neuroscience; 23 (32): 10175-10181 PUBMED
Vertebrate and invertebrate TRPV-like mechanoreceptors (2003)
Mutai, H., Heller, S.
Cell Calcium; 33 (5-6): 471-478 PUBMED
Expression of Frizzled genes in the developing chick eye (2003)
Fuhrmann, S., Stark, M. R., Heller, S.
Gene Expression Patterns; 3 (5): 659-662 PUBMED
TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins (2003)
Keresztes, G., Mutai, H., Heller, S.
BMC Genomics; 4 (1): 24 PUBMED
2002
Parvalbumin 3 is an abundant Ca2+ buffer in hair cells (2002)
Heller, S., Bell, A. M., Denis, C. S., Choe, Y., Hudspeth, A. J.
JARO - Journal of the Association for Research in Otolaryngology; 3 (4): 488-498 PUBMED
Molecular screens for inner ear genes (2002)
Heller, S.
Journal of Neurobiology; 53 (2): 265-275 PUBMED
Application of physiological genomics to the study of hearing disorders (2002)
Heller, S.
Journal of Physiology; 543 (1): 3-12 PUBMED
A unified nomenclature for the superfamily of TRP cation channels (2002)
Montell, C., Birnbaumer, L., Flockerzi, V., Bindels, R. J., Brudorf, E. A., Caterina, M. J., Clapham, D. E., Harteneck, C., Heller, S., Julius, D., Kojima, I., Mori, Y., Penner, R., Prawitt, D., Scharenberg, A. M., Schultz, G., Shimizu, N., Zhu, M. X.
Molecular Cell; 9 (2): 229-231 PUBMED
2000
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor (2000)
Liedtke, W., Choe, Y., Marti-Renom, M. A., Bell, A. M., Denis, C. S., Sali, A., Hudspeth, A. J., Friedman, J. M., Heller, S.
Cell; 103 (3): 525-535 PUBMED
A novel conserved cochlear gene, OTOR: Identification, expression analysis, and chromosomal mapping (2000)
Robertson, N. G., Heller, S., Lin, J. S., Resendes, B. L., Weremowicz, S., Denis, C. S., Bell, A. M., Hudspeth, A. J., Morton, C. C.
Genomics; 66 (3): 242-248 PUBMED
1998
Molecular markers for cell types of the inner ear and candidate genes for hearing disorders (1998)
Heller, S., Sheane, C. A., Javed, Z., Hudspeth, A. J.
PNAS - Proceedings of the National Academy of Sciences of the United States of America; 95 (19): 11400-11405 PUBMED
Two deaf mice, two deaf mice ... (1998)
Heller, S., Hudspeth, A. J.
Nature Medicine; 4 (5): 560-561 PUBMED
Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction(1998)
Robertson, N. G., Lu, L., Heller, S., Merchant, S. N., Eavey, R. D., McKenna, M., Nadol, J. B., Miyamoto, R. T., Linthicum, F. H., Neto, J. F., Hudspeth, A. J., Seidman, C. E., Morton, C. C., Seidman, J. G.
Nature Genetics; 20 (3): 299-303 PUBMED
A transient role for ciliary neurotrophic factor in chick photoreceptor development (1998)
Fuhrmann, S., Heller, S., Rohrer, H., Hofmann, H. D.
Journal of Neurobiology; 37 (4): 672-683 PUBMED
The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling (1998)
Geissen, M., Heller, S., Pennica, D., Ernsberger, U., Rohrer, H.
Development; 125 (23): 4791-4802 PUBMED
Differential regulation of ciliary neurotrophic factor receptor-alpha expression in all major neuronal cell classes during development of the chick retina (1998)
Fuhrmann, S., Kirsch, M., Heller, S., Rohrer, H., Hofmann, H. D.
Journal of Comparative Neurology; 400 (2): 244-254 PUBMED
1997
Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chicken's cochlea (1997)
Rosenblatt, K. P., Sun, Z. P., Heller, S., Hudspeth, A. J.
Neuron; 19 (5): 1061-1075 PUBMED
Onset of CNTFR alpha expression and signal transduction during neurogenesis in chick sensory dorsal root ganglia (1997)
Von Holst, A., Heller, S., Junghans, D., Geissen, M., Ernsberger, U., Rohrer, H.
Developmental Biology; 191 (1): 1-13 PUBMED
1996
Extrinsic signals in the developing nervous system: The role of neurokines during neurogenesis (1996)
Heller, S., Ernsberger, U., Rohrer, H.
Perspectives on Developmental Neurobiology; 4 (1): 19-34 PUBMED
1995
Analysis of function and expression of the chick GPA receptor (GPAR-alpha) suggests multiple roles in neuronal development (1995)
Heller, S., Finn, T. P., Huber, J., Nishi, R., Geissen, M., Puschel, A. W., Rohrer, H.
Development; 121 (8): 2681-2693 PUBMED
1993
GPA and CNTF produce similar effects in sympathetic neurons but differ in receptor-binding (1993)
Heller, S., Huber, J., Finn, T. P., Nishi, R., Rohrer, H.
Neuroreport; 5 (3): 357-360 PUBMED
1992
Bioluminescence-based detection of genetically engineered microorganisms in nonsterile river water (1992)
Heller, S., Bühler, S., Kilz, S., Mieschendahl, M.
Microbial Releases : Viruses, Bacteria, Fungi; 1 (1): 35-39 PUBMED